The US is on high alert and actively preparing for a “significant” attack within the next week by Iran targeting Israeli or American assets in the region in response to Monday’s Israeli strike in Damascus that killed top Iranian commanders, a senior administration official tells CNN.

Senior US officials currently believe that an attack by Iran is “inevitable” – a view shared by their Israeli counterparts, that official said. The two governments are furiously working to get in position ahead of what is to come, as they anticipate that Iran’s attack could unfold in a number of different ways – and that both US and Israeli assets and personnel are at risk of being targeted.

A forthcoming Iranian attack was a major topic of discussion on President Joe Biden’s phone call with Israeli Prime Minister Benjamin Netanyahu on Thursday.

As of Friday, the two governments did not know when or how Iran planned to strike back, the official said.

A direct strike on Israel by Iran is one of the worst-case scenarios that the Biden administration is bracing for, as it would guarantee rapid escalation of an already tumultuous situation in the Middle East. Such a strike could lead to the Israel-Hamas war broadening into a wider, regional conflict – something Biden has long sought to avoid.

Iran vowed to take revenge after Israel’s airstrike on Iran’s embassy complex in Syria, which killed at least seven officials. Mohammed Reza Zahedi, a top commander in Iran’s elite Revolutionary Guards (IRGC), and senior commander Mohammad Hadi Haji Rahimi were among those killed, according to Iran’s Foreign Ministry.

At least six Syrian citizens were also killed, Iranian state television reported on Tuesday.

The US was quick to inform Iran that the Biden administration was not involved and had no advance knowledge of Monday’s strike on the embassy and has warned Iran against coming after American assets.

“The United States had no involvement in the strike and we did not know about it ahead of time,” a National Security Council spokesperson told CNN earlier this week.

This is a breaking story and will be updated.

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